Season 2/Single Episode Guest Stars

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 * Robert Blanche as Franco (7 episodes)
 * Christian Lagadec as Renard's Confidant (7 episodes)
 * Danny Bruno as Bud (6 episodes)
 * James Frain as Eric Renard (6 episodes)
 * Mary McDonald-Lewis as Frau Pech (4 episodes)
 * Sharon Sachs as Harper (4 episodes)
 * Shohreh Aghdashloo as Stefania Vaduva Popescu (3 episodes)
 * Bertila Damas as Pilar (3 episodes)
 * Michael Grant Terry as Ryan Smulson (3 episodes)
 * Reg E. Cathey as Baron Samedi (2 episodes)
 * Mary Elizabeth Mastrantonio as Kelly Burkhardt (2 episodes)
 * Jessica Tuck as Catherine Schade (2 episodes)
 * Lisa Vidal as Lauren Castro (2 episodes)
 * Mike Dopud as Marnassier (2 episodes)
 * Jessen Noviello as David Esquibel (2 episodes)
 * Jim Crino as Leroy Estes (2 episodes)
 * Robert Alan Barnett as Matthew (2 episodes)
 * Timothy Whitcomb as Al the Tow Truck Driver (2 episodes)
 * Jenny McShane as Lilly O'Hara (2 episodes)
 * Michael Agostini as Carter (2 episodes)
 * Luke King as Lucas (2 episodes)
 * Kamyar Jahan as Miguel (2 episodes)
 * Jean-Liu Boucherot as Yanko (2 episodes)
 * Tabor Helton as Businessman (2 episodes)
 * Glen Baggerly as Lead Officer (2 episodes)
 * Tony Calvino as Officer (2 episodes)
 * Rick Walters as SERT #2 (2 episodes)

Single Episode Guest Stars
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 * Brian Tee as Akira Kimura ({{ep|201}})
 * Ryan Sands as FBI Agent Lofthouse ({{ep|202}})
 * Mark Pellegrino as Jarold Kampfer ({{ep|203}})
 * John Pyper-Ferguson as Hayden Walker ({{ep|203}})
 * Maddie Hasson as Carly Kampfer ({{ep|203}})
 * Kevin Shinick as Ryan Gilko ({{ep|204}})
 * Jonathan Scarfe as Lance Calvin ({{ep|205}})
 * Kristina Anapau as Megan Marston ({{ep|205}})
 * Jeanine Jackson as Paula ({{ep|205}})
 * Jaime Ray Newman as Angelina Lasser ({{ep|206}})
 * Alice Evans as Mia Gaudot ({{ep|206}})
 * Matt Gerald as Arbok ({{ep|206}})
 * Josh Stewart as William Granger ({{ep|207}})
 * Jade Pettyjohn as April Granger ({{ep|207}})
 * Mary Page Keller as Dr. Higgins ({{ep|208}})
 * Logan Miller as Pierce Higgins ({{ep|208}})
 * Titus Makin Jr. as Brandon Kingston ({{ep|208}})
 * Kate del Castillo as Valentina Espinosa ({{ep|209}})
 * Angela Alvarado Rosa as The Woman ({{ep|209}})
 * David Barrera as Luis Alvarez ({{ep|209}})
 * Michael Maize as Adrian Zayne ({{ep|210}})
 * Jason Gedrick as Craig Ferren ({{ep|211}})
 * Jamie McShane as John Kreski ({{ep|211}})
 * Callard Harris as Cole Pritchard ({{ep|214}})
 * Lili Mirojnick as Krystal Fletcher ({{ep|214}})
 * Kieren Hutchison as Andre ({{ep|215}})
 * Jenny Wade as Casey ({{ep|215}})
 * Megan Henning as Molly Fisk ({{ep|215}})
 * Eric Lange as Dominick Spinner ({{ep|216}})
 * Camille Chen as Jenna Marshall ({{ep|216}})
 * Brian T. Finney as Barry Kellogg ({{ep|217}})
 * Gill Gayle as Markus Hemmings ({{ep|218}})
 * Eric Tiede as Vincent ({{ep|219}})
 * Erin Way as Jocelyn ({{ep|219}})
 * Nora Zehetner as Khloe Sedgwick ({{ep|220}})
 * Brian Gant as Anton Cole ({{ep|220}})