Talk:Hybrid/@comment-99.121.210.154-20150512043620/@comment-2601:1C0:CB00:50A6:492A:1728:9501:81B3-20180605135345

Unfotunately, your assessment is flawed -  if we are indeed looking at this following real life rules of genetics. First off, my credentials: I am a Molecular Biologist & Geneticist I hold a degrees and teach courses in these areas.

You have the general idea of Mendelian Genetics correct and you obviously have knowledge of punnet squares. The fault lies within your attributing a 3rd possible allele (g for Genträge) - which is not what the explanation given by Rosalee and Monroe means - and in your creating exceptions to explain why the written proof is not supported by the explanations given in-story. The rules of Genetics are constant. There are mutations, gender related caveats and varying degrees of co-dominance as well as degrees of incomplete-dominance; but there are no exceptions. I'll expound below.

We'd need to tweak your assessment to get this correctly sorted. You started with a heterozygous pure Wesen, which (1) is an oxymoron (heterozygous is the antithesis of "pure" or "Wild-Type" when talking genetics), (2) discredits your proof. To write a genetics proof, you have to start with the "Purest" or "Wild-Type" Version of each genotype, representing & noting all potential alleles, genotypes and corresponding phenotypes. In this case, those are:

(1) Homozygous Wesen (WW) -this is the only was a Wesen/ Wesen cross will always generate Wesen offspring

(2) Homozygous Human or Kehrseite  (KK)

(3) Grimm - which is a human with "Grimm" gene mutation(s) in one of their K alleles (for clarity, we'll call this GK); deductive reasoning allows us to conclude:

[A] Being a Grimm is the product of various mutations on Kehrseite (K) alleles - one of which they talk about when Nick loses his Grimm Sight (the number of cones in the eyes allowing him to see an extended spectrum compared to other humans) - reason being, Kelly is a Grimm, but the alleles from his mother are Wesen (Adalind). Yet he is still a human, so his being a Grimm is a product of getting K alleles with certain mutations from Nick which seem to trump any influence from his Wesen alleles.

[B] Grimms are generally Heterozygous as (1) they are rare and (2) offspring of Grimms aren't necessarily going to become Grimms themselves (Nick's Uncle George, for instance). "Generally" because it stands to reason that a "GG" genotype is possible if 2 Grimms got busy (as shown below). This is never touched on, so we don't know if this would be, like: an Uber Grimm, a non-viable combination, a viable, but sterile, combination or what. Still, however, remember they would be human; we are only using "G" to indicate a "K" allele with Grimm Mutations.

(4) We have observed that a WK or WG genotype (Wesen x Kehrseite union) produce cases of Co-Dominance (Captain Renard) and Incomplete Dominance (Diana Shade-Renard) and what is suggested to be Complete Dominance (Kelly Shade-Burkhardt). However, these are all examples  in each the Wesen is a Hexen-/Zauber-Biest. So, inductive reasoning dictates there are any number of variations on the phenotypic expressions of heterozygous individuals.

NOTE: a "Pure Wesen" is not Wg; there is no "g" allele, as that would imply the possibility of a "gg" genotype, which doesn't correspond with either of our phenotypes (Wesen & Human). From the given description a Kehseite Genträge is a Kehrseite x Wesen cross which genotypically means Heterozygous (WK) offspring; not Wg.

Cross-breeding doesn't magically create a 3rd, heretofore non-existent, allele (g) and subsequently formerly impossible genotypes (Wg, Kg, etc). Genotypes are determined utilizing whatever alleles are available from/present in the parents. Except in cases of mutation arguably, new alleles and genotypes are not possible. New PHENOTYPES however are (via incomplete and codominance), and I think that may be where you are getting tripped up.

ENOUGH TALK. Let's work these out:

Wesen x Wesen (SAME)             Kehseite x Kehseite                        Wesen x Kehseite

W       W                                     K          K                                       K           K

W   WW    WW                            K    KK       KK                              W   WK        WK

W   WW    WW                            K    KK       KK                              W   WK        WK

Grimm x Grimm                          Grimm x Kehseite                           Grimm x Wesen

G        K                                      K        K                                        W           W

G     GG     GK                           G     GK       GK                              G   GW         GW

K      GK     KK                            K     KK        KK                              K    WK         WK

In words:

Wesen x Wesen (SAME) = 100% Wesen

Kehseite x Kehseite = 100% Kehseite

Grimm x Grimm = 50% Grimm, 25% Kehseite, 25% Whatever GG would mean phenotypically

Grimm x Kehseite = 50% Grimm, 50% Kehseite

BOTH OF WHICH COULD BE THE CASE FOR NICK'S MOTHER AND HER SIBLINGS. STATISCALLY SPEAKING, WE'D NEED ONE MORE CHILD TO DETERMINE IF NICK'S GRANDMOTHER WAS A GRIMM OR KEHSEITE (Kelly tells Nick his grandfather was a Grimm).

The last 2 are a bit more convoluted.

Wesen x Kehseite = Genotypically, 100% of the offspring would be Heterozygous or WK.

This is where you get into the nitty gritty that they reallly don't explain. We observed a WK genotype can mean:

Co-dominance (Sean Renard);

Incomplete Dominance (Diana Shade-Renard); and

According to Monroe and Rosalee, there's a 50/50 PHENOTYPIC probability of Wesen or Kehseite-Gentäge offspring. This has a high probability of being incorrect as we have seen 2 versions of offspring, neither of which were Kehseite-Gentäge. Induction says, the most probable explanation - that also allows Monroe/Rosalee's statement to be true - is for Co-dominance & Incomplete Dominance to both be considered "Wesen" and for Wesen genes to be incapable of Complete Dominance.

In plain English, this would mean that Kehseite genes are either stronger or comparable to Wesen genes, depending on the Wesen. So, phenotypically, you would end up with:

~25% Co-Dominance

~25% Incomplete Dominance

50% Kehseite-Gentäge. meaning a Kehseite whose DNA is 1/2 Wesen, but because of physiological factors, it is not expressed. That doesn't make the Wesen DNA recessive - in a different combination, it might share dominance in some way or even dominate. It just requires the right conditions in order to be expressed. They would all have the same genotypes, though, regardless.

This suggests that with the right mate, 2 long lines of, supposed, Kehseite could suddenly produce Wesen offspring. A Wesen mating with a Kehseite-Gentäge, from a long line of assumed Kehseite, with a different Wesen ancestry could produce a number of interesting results as far as offspring (3 in particular spring to mind).

This then, must be applied to all other crosses:

Grimm x Wesen = 50% Grimm, 25% Kehseite-Gentäge, 25% Wesen (incomplete or co-dominant phenotype)

This is all over-simplified as I'm sure the type of Wesen matters; there's not just "a" single set of Wesen genes, there have to be a wide variety to allow for the variety of types/ethnicities/breeds.

Bringing us to the very last Cross:

Wesen Type 1 x Wesen Type 2 = There are a number of ways this could shake out - especially since almost certainly every type of Wesen have some traits that are more dominant relative to other Wesen (much like Kehseite with hair color and eye color, etc).

CONCLUSION: When it comes down to it, the explanation given by Monroe and Rosalee doesn't make complete sense genetically. Parts of it are genotypically sound, but some of their statements aren't probable if other statements they made - and what we have observed in the show - are true.